Syntheses of Neamine Derivatives and Their Antibacterial Activities
نویسندگان
چکیده
منابع مشابه
SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES
Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3 yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl (or propyl) arnine with 4. Addition of hydrazine hydrate to compound 4a gave 2- (2- pyridyl) quinoline-4-carboxylic acid hydrazide (6). Reaction of l...
متن کاملSynthesis and antibacterial activity of novel neamine derivatives.
Synthesis and activity of derivatives at the O5 or O6 positions of 1-N-((S)-4-amino-2-hydroxybutyryl)-3',4'-dideoxyneamine, which is the neamine moiety of arbekacin, were reported. Among these results, the 5-O-aminoethylaminocarbonyl derivative showed effective activity against Staphylococcus aureus expressing a bifunctional aminoglycoside-modifying enzyme AAC(6')-APH(2'').
متن کاملSYNTHESES, ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED 1,2, CTRIMOLES
The reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1) with thionyl chloride afforded the corresponding acyl chloride 2. The reaction of compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)- thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole- 2-y1)-2,4-dihydro-3H- l,2,4-triazole-3- thione 4. Alkylatio...
متن کاملSyntheses and activities of some bactobolin derivatives.
Some derivatives of bactobolin were prepared from bactobolin by dehydration or substitution reactions through tris(dimethylamino)alkoxyphosphonium salt formation. A derivative with low toxicity, 6-deoxybactobolin, showed moderate activity against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus.
متن کاملsyntheses, antibacterial and antifungal activities of 2-aryl-4- quinoline- carboxamide derivatives
reaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). reaction of diazomethane with compound 3 yielded the ester 4. compound 5 was prepared from the reaction of n, n'-dialkylethyl (or propyl) arnine with 4. addition of hydrazine hydrate to compound 4a gave 2- (2- pyridyl) quinoline-4-carboxylic acid hydrazide (6). reaction of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1974
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.22.1151